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KMID : 0931320230230040277
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대한상부위장관.헬리코박터학회지
2023 Volume.23 No. 4 p.277 ~ p.282
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Comparison of Helicobacter pylori Eradication Rates Using Standard Triple Therapy and Sequential Therapy
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Kim Yu-Ri
Ahn Ji-Yong
Jung Hwoon-Yong
Noh Jin-Hee
Na Hee-Kyong
Jung Kee-Wook
Lee Jeong-Hoon
Kim Do-Hoon
Choi Kee-Don
Song Ho-June
Lee Gin-Hyug
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Abstract
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Objectives: The incidence of treatment failures following standard triple therapy (STT) for Helicobacter pylori eradication (HPE) has reached an unacceptable level. Sequential therapy (SQ) has emerged as a promising approach to counteract the escalation of antibiotic resistance. In this study, we used a chronological cohort dataset to conduct a comparative analysis of the eradication rates, compliance, and adverse events associated with the 7-day STT and SQ.
Methods: A total of 789 patients underwent HPE treatment at Asan Medical Center between July 2013 and August 2017. Among them, 378 received a 7-day STT and 411 received a 10-day SQ. Baseline clinical data and treatment parameters were compared between the two treatment groups.
Results: SQ demonstrated an eradication rate of 84.7% (348/411), which was superior to that of the 7-day STT (74.1%; p<0.001). The incidence of adverse events was also higher in the SQ group than in the STT group (17.5% vs. 11.1%; p=0.01). Nonetheless, treatment compliance was not significantly different between the groups (98.1% [SQ] vs. 96.8% [STT]; p=0.38). Among the patients undergoing second-line eradication, the SQ group displayed a lower eradication rate than the STT group (77.8% vs. 92.4%; p=0.028). Notably, the overall eradication rate did not differ significantly between the two groups (98.3% [STT] vs. 97.4% [SQ]; p=0.56).
Conclusions: SQ exhibited superior efficacy compared with the 7-day STT as a first-line H. pylori treatment. Thus, SQ holds potential to serve as the replacement for the 7-day STT in treatment-naive patients.
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KEYWORD
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Helicobacter pylori, Eradication, Antibiotics, Standard triple therapy, Sequential therapy
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